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master's thesis
Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama
2019. urn:nbn:hr:182:815624
Vranješ, Sara
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Vranješ, S. (2019). Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:815624

Vranješ, Sara. "Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:815624

Vranješ, Sara. "Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:815624

Vranješ, S. (2019). 'Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:182:815624

Vranješ S. Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2019 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:182:815624

S. Vranješ, "Ispitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:182:815624

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Metadata
TitleIspitivanje mogućnosti primjene eutektičkih otapala kao zamjene za standardna organska otapala u SN2 reakcijama
Title (english)Investigating potential use of eutectic solvents as a substitute for standard organic solvents in SN2 reactions
AuthorSara Vranješ
MentorMartina Šrajer Gajdošik (mentor)
MentorDajana Gašo-Sokač (komentor)
Committee memberMarija Jozanović (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberDajana Gašo-Sokač (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2019-10-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U svrhu istraživanja ekološki prihvatljive alternative standardnim organskim otapalima u SN2 reakcijama, u ovome je radu ispitana mogućnost primjene eutektičkih otapala kao pogodnog medija u reakcijama kvaternizacije. Stoga su izvedene reakcije kvaternizacije nikotinamida s tri različito supstituirana 2-bromacetofenona. Reakcije su provedene konvencionalnom, mikrovalnom i ultrazvučnom sintetskom metodom. Provedeno istraživanje pokazalo je da su najpogodnija eutektička otapala na bazi kolin-klorida, kao akceptora vodikove veze, i uree, glicerola, acetamida i levulinske kiseline u molarnom omjeru 1 : 2, kao donora vodikove veze. Uporabom mikrovalnog zračenja i ultrazvuka znatno je skraćeno vrijeme reakcija, a konačna iskorištenja povećana su u odnosu na konvencionalnu metodu sinteze.
Abstract (english)
In this study, the possibility of using eutectic solvents as a suitable medium in quaternization reactions was examined to investigate an environmentally friendly alternative to standard organic solvents in SN2 reactions. Therefore, quaternization reactions of nicotinamide were performed using three differently substituted 2-bromoacetophenones. Reactions were conducted using a conventional, microwave and ultrasonic synthetic method. Research has shown that the most suitable eutectic solvents are based on choline-chloride, as hydrogen bond acceptor, and urea, glycerol, acetamide and levulinic acid in a molar ratio of 1: 2, as hydrogen bond donors. The use of microwave radiation and ultrasound significantly reduced reaction time, and final yields were increased in comparison to the conventional synthesis method.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:815624
Study programmeTitle: Graduate University Study of Chemistry; research direction
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-14 08:50:07