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undergraduate thesis
Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa
2017. urn:nbn:hr:182:617591
Martinčić, Monika
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Martinčić, M. (2017). Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:617591

Martinčić, Monika. "Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:182:617591

Martinčić, Monika. "Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:182:617591

Martinčić, M. (2017). 'Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 15 March 2023, https://urn.nsk.hr/urn:nbn:hr:182:617591

Martinčić M. Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2017 [cited 2023 March 15] Available at: https://urn.nsk.hr/urn:nbn:hr:182:617591

M. Martinčić, "Mitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:182:617591

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Metadata
TitleMitohondrijski proteini razdvajanja i otpornost na inzulin kod dijabetesa
Title (english)Uncoupling proteins and insulin resistence in diabetes
AuthorMonika Martinčić
MentorMartina Šrajer Gajdošik (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2017-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Mitohondrijski proteini razdvajanja (UCP) su nosači aniona koji se nalaze u unutrašnjoj membrani mitohondrija i omogućuju protok protona iz citoplazme u matriks. Oni raspršuju proton motornu silu, te umjesto sinteze ATP-a dolazi do stvaranja topline. UCP-ovi se nalaze u raznim tkivima organizma i pretpostavlja se da utječu na razvoj dijabetesa. Zbog djelovanja UCP-a dolazi do smanjenog lučenja inzulina te do inzulinske rezistencije, stanje u kojem dolazi do smanjenog odgovora tkiva na ovaj hormon. Sam inzulin sintetizira se u beta stanicama gušterače, te se izlučuje kada su stanice potaknute određenom količinom glukoze u krvi. Glukoza ulazi u stanice pomoću transportera glukoze (GLUT). U ovom završnom radu proučit ćemo što je dijabetes te kako izgleda metabolizam glukoze. Reći ćemo kako disfunkcija beta stanica utječe na razvoj ove bolesti i nastanak inzulinske rezistencije. Mehanizam djelovanja samih UCP-ova nije još u potpunosti razjašnjen, ali postoje tri pretpostavke koje ćemo navesti.
Abstract (english)
Uncoupling proteins (UCP) are anion carriers expressed in the mitochondrial inner membrane that enable proton flow from cytoplasm to the matrix. They disperse the proton motor force resulting in heat production instead of ATP synthesis. UCPs are found in various tissues and are supposedly have an affect on development of diabetes. Due to UCPs activity, insulin secretion is reduced and insulin resistance, a condition in which cells do not respond normally to the insulin, is developed. Insulin synthesis takes place in pancreatic beta cells and it's secretion is induced by specific concentrations of glucose. Glucose transporters (GLUT) allow glucose to enter the cells. In this work, we will discuss what diabetes is and how glucose metabolism works. We will find out how dysfunction of beta cells affects diabetes and insulin resistance. The mechanism of action of UCPs is still debated but three potential mechanism will be discussed as well.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:617591
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-01-05 11:24:51