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undergraduate thesis
Dijagnostička uloga glikoziliranog hemoglobina - HbA1c
2017. urn:nbn:hr:182:869740
Košćak, Marta
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Košćak, M. (2017). Dijagnostička uloga glikoziliranog hemoglobina - HbA1c (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:869740

Košćak, Marta. "Dijagnostička uloga glikoziliranog hemoglobina - HbA1c." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:182:869740

Košćak, Marta. "Dijagnostička uloga glikoziliranog hemoglobina - HbA1c." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:182:869740

Košćak, M. (2017). 'Dijagnostička uloga glikoziliranog hemoglobina - HbA1c', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 26 October 2024, https://urn.nsk.hr/urn:nbn:hr:182:869740

Košćak M. Dijagnostička uloga glikoziliranog hemoglobina - HbA1c [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2017 [cited 2024 October 26] Available at: https://urn.nsk.hr/urn:nbn:hr:182:869740

M. Košćak, "Dijagnostička uloga glikoziliranog hemoglobina - HbA1c", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:182:869740

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Metadata
TitleDijagnostička uloga glikoziliranog hemoglobina - HbA1c
Title (english)Diagnostic aspects of glycosylated hemoglobin - HbA1c
AuthorMarta Košćak
MentorKatarina Mišković Špoljarić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2017-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Hemoglobin \( A_{1c}\) (\( HbA_{1c}\)) naziva se „zlatnim standardom“ uredne glikemije, izražene u postotcima,\( HbA_{1c}\) ≤ 7%. \( HbA_{1c}\) nastaje procesom glikacije koja obuhvaća reakciju glukoze nakupljene u krvi i eritrocita, te se koristi kao sredstvo praćenja dijagnoze i terapijske ispravnosti kod osoba oboljelih od dijabetesa. Iako se određivanje \( HbA_{1c}\) primjenjuje više od 40 godina, dugo je vremena trebalo da se provede analitička i klinička standardizacija, nađe odgovarajuća referentna metoda i proizvede primarni referentni materijal. Prvotno korištena metodologija bila je precizna ali joj je nedostajala specifičnost. Dugogodišnjim istraživanjima proizveden je referentni materijal, definiran analit te kao referentna metoda postavljen IFCC referentni sustav. Unatoč tomu, referentna metoda imala je previše odstupanja. IFCC-ov referentni sustav snizio bi apsolutne koncentracije \( HbA_{1c}\) , u odnosu na do tada korištene vrijednosti, što bi rezultiralo pomutnjom, kako među zdravstvenim djelatnicima tako i među osobama oboljelim od dijabetesa i njihovim obiteljima. Inzistiranje zdravstvenih stručnjaka za zadržavanjem postojećih metoda potaknulo je projekt „prosječna glikemija“. Krajnji cilj projekta bio je ponovno definiranje \( HbA_{1c}\) u smislu podudaranja vrijednosti \( HbA_{1c}\) s koncentracijom glukoze u krvi. Globalna harmonizacija određivanja \( HbA_{1c}\) je izrazito važna za postavljanje \( HbA_{1c}\) pod primarnu zdravstvenu zaštitu, te je upravo taj proces i njegova dijagnostička uloga, kako u svijetu tako i u Hrvatskoj, tema ovoga rada.
Abstract (english)
Hemoglobin \( A_{1c}\) (\( HbA_{1c}\)) is called „golden standard“ of a good glycaemic control expressed in percentage as \( HbA_{1c}\) value ≤ 7%. \( HbA_{1c}\) is formed by the glycation process which includes reaction between glucose and red blood cells and it has been used as a clinical standard of diagnosis and therapeutic suitability for people with diabetes. Although \( HbA_{1c}\) is being used for more than 40 years, it took a long time until analytical and clinical standardization found an appropriate reference method and the primary reference material. The first used methods were precise but it was lacking specificity. Long-term studies produced a reference material, defined analyte and as a specific reference method called IFCC reference system. Despite that, reference method had too many deviations. IFCC's reference system would reduce the absolute \( HbA_{1c}\) levels, compared to a previously used method. It was considered that could cause confusion among professionals along with patients and their families. Medical experts wanted to retain existing methods and it started a project "mean blood glucose". The ultimate project's goal was to redefine \( HbA_{1c}\) in terms of matching the value of the \( HbA_{1c}\) concentration of glucose in the blood. Global harmonization of determining HbA1c is extremely important for setting HbA1c under primary health care and its process and diagnostic role, both worldwide and in Croatia, are the subject of this paper.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:869740
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-01-10 10:29:59