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undergraduate thesis
Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova
2021. urn:nbn:hr:182:001133
Jurić, Ivona
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Jurić, I. (2021). Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:001133

Jurić, Ivona. "Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:001133

Jurić, Ivona. "Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:001133

Jurić, I. (2021). 'Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 15 March 2023, https://urn.nsk.hr/urn:nbn:hr:182:001133

Jurić I. Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2021 [cited 2023 March 15] Available at: https://urn.nsk.hr/urn:nbn:hr:182:001133

I. Jurić, "Teoretske metode za racionalan odabir tvari za sintezu kokristala lijekova", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:182:001133

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Metadata
TitleTeoretske metode za racionalan odabir tvari za sintezu kokristala lijekova
Title (english)Theoretical methods for the rational selection of coformers to form drug co-crystals
AuthorIvona Jurić
MentorAleksandar Sečenji (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2021-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Kada je riječ o farmaceutskoj industriji, posljednjih nekoliko godina se kokristalima pridaje sve veća pažnja. Riječ je o višekomponentnim supramolekularnim oblicima koji se sastoje od nenabijene aktivne farmaceutske tvari i koformera, koji mogu biti povezani vodikovom vezom, halogenom vezom, Londonovom silom i dr. Glavna svrha proučavanja i priprave kokristala je poboljšanje fizikalno – kemijskih svojstava kao što su topljivost, stabilnost, brzina otapanja i higroskopnost, ali bez kovalentne modifikacije lijeka. Jedna od ključnih koraka u stvaranju kokristala je odabir koformera. Kako bi se olakšalo stvaranje farmaceutskog kokristala postoje teoretske metode koje olakšavaju odabir koformera, a to su: COSMO – RS, MEPS, usporedba energije kristalne rešetke, Hirshfeldova površinska analiza, Hansenov parametar topljivosti i pKa. Upravo će u ovom radu biti riječ o teoretskim metodama za racionalan odabir tvari za sintezu farmaceutskog kokristala.
Abstract (english)
When it comes to the pharmaceutical industry, great attention has been paid to co-crystals in recent years. These are multicomponent supramolecular forms consisting of an uncharged active pharmaceutical substance and coformers, which can be connected by a hydrogen bond, halogen bond, London force, etc. The main purpose of studying co-crystals is to improve physicochemical properties such as solubility, stability, dissolution rate and hygroscopicity, but without a covalent drug modification. One of the most complicated steps in creating a co-crystal is choosing a coformer. In order to facilitate the formation of a pharmaceutical co-crystal, there are theoretical methods that facilitate the selection of coformers, namely: COSMO - RS, MEPS, crystal lattice energy comparison, Hirshfeld surface analysis, Hansen solubility parameter and pKa. This paper will discuss the theoretical methods for the rational selection of substances for the synthesis of pharmaceutical co-crystals.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:001133
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-08-01 08:13:43