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undergraduate thesis
Poremećaji u metabolizmu aminokiselina
2022. urn:nbn:hr:182:991047
Hamzić, Arijana
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Hamzić, A. (2022). Poremećaji u metabolizmu aminokiselina (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:991047

Hamzić, Arijana. "Poremećaji u metabolizmu aminokiselina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:991047

Hamzić, Arijana. "Poremećaji u metabolizmu aminokiselina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:991047

Hamzić, A. (2022). 'Poremećaji u metabolizmu aminokiselina', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:991047

Hamzić A. Poremećaji u metabolizmu aminokiselina [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2022 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:182:991047

A. Hamzić, "Poremećaji u metabolizmu aminokiselina", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:182:991047

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Metadata
TitlePoremećaji u metabolizmu aminokiselina
Title (english)Disorders of amino acid metabolism
AuthorArijana Hamzić
MentorMartina Šrajer Gajdošik (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2022-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Applied Chemistry
Abstract
Aminokiseline su osnovne građevne jedinice proteina. Građene su od središnjeg ugljikovog atoma na kojeg su vezane četiri skupine, amino-skupina, vodikov atom, karboksilna-skupina i bočni ogranak koji čini svaku aminokiselinu jedinstvenom po svojoj strukturi. Svakodnevno organizam razgrađuje i sintetizira aminokiseline stoga u njihovom metabolizmu može doći do pogrešaka koje dovode do raznih poremećaja. Najčešća pogreška koja dovodi do razvitka poremećaja je nedostatak bitnih enzima koji prevode aminokiseline iz jedne u drugu. Zbog toga u organizmu dolazi do nakupljanja štetnih međuprodukata u krvi ili urinu i zbog kojih dolazi do razvitka raznih bolesti. Najčešći poremećaj u metabolizmu aminokiselina je fenilketonurija do koje dolazi zbog nedostatka enzima koji katalizira pretvorbu fenilalanina u tirozin, a karakteriziraju ju ponajviše poteškoće u mentalnom razvoju. Uz fenilketonuriju u poremećaje metabolizma aminokiselina ubrajaju se i bolest urina mirisa javorovog sirupa, homocistinurija, tirozinemija, neketotička hiperglicinemija, te poremećaji u ciklusu uree koji su jednako učestali ali i opasni.
Abstract (english)
Amino acids are the basic building blocks of proteins. They are built of a central carbon atom to which four groups are attached, an amino group, a hydrogen atom, a carboxyl group and a side branch that makes each amino acid unique in its structure. Every day, the body breaks down and synthesizes amino acids, therefore mistakes can occur in their metabolism that lead to various disorders. The most common mistake that leads to the development of disorders is the lack of essential enzymes that convert amino acids from one to another. Because of this, the body accumulates harmful intermediate products in the blood or urine, which leads to the development of various diseases. The most common disorder in the metabolism of amino acids is phenylketonuria, which occurs due to the lack of an enzyme that catalyzes the conversion of phenylalanine to tyrosine, and is characterized mainly by difficulties in mental development. In addition to phenylketonuria, disorders of amino acid metabolism include maple syrup urine disease, homocystinuria, tyrosinemia, non-ketotic hyperglycinemia, and disorders in the urea cycle, which are equally frequent but also dangerous.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:991047
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-11-02 09:04:22