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undergraduate thesis
Inhibitori ciklooksigenaze 2 (COX-2)
2022. urn:nbn:hr:182:328359
Magić, Dina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Magić, D. (2022). Inhibitori ciklooksigenaze 2 (COX-2) (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:328359

Magić, Dina. "Inhibitori ciklooksigenaze 2 (COX-2)." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:328359

Magić, Dina. "Inhibitori ciklooksigenaze 2 (COX-2)." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:328359

Magić, D. (2022). 'Inhibitori ciklooksigenaze 2 (COX-2)', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 07 December 2024, https://urn.nsk.hr/urn:nbn:hr:182:328359

Magić D. Inhibitori ciklooksigenaze 2 (COX-2) [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2022 [cited 2024 December 07] Available at: https://urn.nsk.hr/urn:nbn:hr:182:328359

D. Magić, "Inhibitori ciklooksigenaze 2 (COX-2)", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:182:328359

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Metadata
TitleInhibitori ciklooksigenaze 2 (COX-2)
Title (english)Cyclooxygenase 2 (COX-2) inhibitors
AuthorDina Magić
MentorAna Amić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2022-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Applied Chemistry
Abstract
Ciklooksigenaza-2 (engl. Cyclooxygenase-2, COX-2) je enzim koji se pojavljuje u bolnim i upaljenim tkivima, dok je u zdravim tkivima uglavnom neaktivan. To je enzim koji katalizira nastanak prostanoida (prostaglandina, tromboksana i prostaciklina), spojeva koji povećavaju upalnu reakciju u organizmu. Kako bi se bol i upala umanjile koriste se različiti inhibitori ovog enzima. Među prvima su se razvili neselektivni inhibitori koji su osim COX-2 inhibirali i rad vrlo sličnog enzima, ciklooksigenaze-1 (engl. Cyclooxygenase-1, COX-1). Kasnija istraživanja su se usredotočila na pronalazak selektivnih inhibitora koji će inhibirati samo rad COX-2. Međutim, takvi su inhibitori pokazali velik broj neželjenih nuspojava. Novija istraživanja se usmjeravaju na pronalazak adekvatnih inhibitora prirodnog porijekla jer oni izazivaju značajno manji broj nuspojava. Također, neki od inhibitora COX-2 pokazali su značajna antikancerogena svojstva zbog čega se ispituju u kombinacijama s raznim kemoterapeuticima.
Abstract (english)
Cyclooxygenase-2 (COX-2) is an enzyme that occurs in painful and inflamed tissues, while it is mostly inactive in healthy tissues. It is an enzyme that catalyses the production of prostanoids (prostaglandins, thromboxanes and prostacyclins), compounds that increase the body's inflammatory response. Various inhibitors of this enzyme are used to reduce pain and inflammation. First developed inhibitors were non-selective inhibitors that, in addition to COX-2, inhibited the work of a very similar enzyme, cyclooxygenase-1 (COX-1). Subsequent research has focused on finding selective inhibitors that will only inhibit COX--2 activity. However, such inhibitors have shown a large number of unwanted side effects. Recent research focus on finding adequate inhibitors of natural origin because they have significantly reduced side effects. Also, some of the COX-2 inhibitors have shown significant anticancer properties which is why they are being tested in combination with various chemotherapeutics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:328359
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-11-02 10:12:04