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undergraduate thesis
Hemoglobin i alosterija
2023. urn:nbn:hr:182:010876
Ramić, Laura
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Ramić, L. (2023). Hemoglobin i alosterija (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:010876

Ramić, Laura. "Hemoglobin i alosterija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:182:010876

Ramić, Laura. "Hemoglobin i alosterija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:182:010876

Ramić, L. (2023). 'Hemoglobin i alosterija', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 27 April 2024, https://urn.nsk.hr/urn:nbn:hr:182:010876

Ramić L. Hemoglobin i alosterija [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2023 [cited 2024 April 27] Available at: https://urn.nsk.hr/urn:nbn:hr:182:010876

L. Ramić, "Hemoglobin i alosterija", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:182:010876

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Metadata
TitleHemoglobin i alosterija
Title (english)Hemoglobin and allostery
AuthorLaura Ramić
MentorMartina Šrajer Gajdošik (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2023-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Applied Chemistry
Abstract
Hemoglobin je kompleksni protein prisutan u crvenim krvnim stanicama i igra ključnu ulogu u transportu kisika i ugljikovog dioksida u organizmu. Sastoji se od četiri podjedinice (dvije alfa i dvije beta podjedinice - α2β2), pri čemu svaka podjedinica sadrži mjesto za vezanje kisika, omogućujući učinkovit prijenos kisika iz pluća do tkiva i organa. Alosterija, važan biokemijski koncept, opisuje promjene u strukturi proteina koje utječu na njegovu funkciju. Kod hemoglobina, alosteričke promjene mijenjaju sposobnost hemoglobina za vezivanje i otpuštanje kisika. To znači da hemoglobin može prilagoditi svoju aktivnost ovisno o uvjetima u okolišu, kao što su pH i koncentracija CO2. Jedan od najpoznatijih primjera alosterije u hemoglobinu je Bohr efekt, gdje promjene u pHvrijednosti okoline utječu na afinitet hemoglobina za kisik. Ovaj mehanizam omogućava hemoglobinu da isporučuje kisik gdje je najpotrebniji u tijelu. Osim toga, hemoglobin može biti moduliran egzogenim faktorima poput organskih fosfata i 2,3-bisfosfoglicerata (BPG).
Abstract (english)
Hemoglobin is a complex protein present in red blood cells and plays a key role in the transportation of oxygen and carbon dioxide in the body. It consists of four subunits (two alpha and two beta subunits - α2β2), with each subunit containing a binding site for oxygen, enabling efficient transfer of oxygen from the lungs to the tissues and organs. Allosterism, an important biochemical concept, describes changes in the protein's structure that affect its function. In the case of hemoglobin, allosteric changes alter its ability to bind and release oxygen. This means that hemoglobin can adjust its activity depending on environmental conditions, such as pH and CO2 concentration. One of the most well-known examples of allosterism in hemoglobin is the Bohr effect, where changes in the pH of the environment influence hemoglobin's affinity for oxygen. This mechanism allows hemoglobin to deliver oxygen where it is most needed in the body. Additionally, hemoglobin can be modulated by exogenous factors such as organic phosphates and 2,3-bisphosphoglycerate (BPG).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:010876
Study programmeTitle: University Undergraduate Study program Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-11-10 08:38:09