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undergraduate thesis
Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova
2018. urn:nbn:hr:182:382625
Oršulić, Katarina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Oršulić, K. (2018). Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:382625

Oršulić, Katarina. "Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:382625

Oršulić, Katarina. "Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:382625

Oršulić, K. (2018). 'Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 11 December 2024, https://urn.nsk.hr/urn:nbn:hr:182:382625

Oršulić K. Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2018 [cited 2024 December 11] Available at: https://urn.nsk.hr/urn:nbn:hr:182:382625

K. Oršulić, "Kaspaze kao ciljne molekule u razvoju antitumorskih lijekova", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:182:382625

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Metadata
TitleKaspaze kao ciljne molekule u razvoju antitumorskih lijekova
Title (english)Caspases as target molecules in antitumor drug developoment
AuthorKatarina Oršulić
MentorMartina Šrajer Gajdošik (mentor)
MentorMarija Paurević (pomoć pri izradi, neposredni voditelj)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2018-07-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Kaspaze su proteaze koje u svom aktivnom mjestu sazdrže cistein te cijepaju proteinski supstrat nakon aspartata. Imaju ulogu u raznim staničnim procesima, uključujući apoptozu, diferencijaciju, upalne odgovore i dr.. Kod ljudi je prisutno 12 kaspaza, a dijele se na kaspaze koje sudjeluju u procesu apoptoze i kaspaze uključene u upalnom odgovoru. Kaspaze koje sudjeluju u apoptozi se dijele na kaspaze inicijatore i kaspaze izvršitelje. Iako sudjeluju u mnogim staničnim procesima, u tumorsikim se stanicama kaspaze najčešće povezuju s apoptozom, pri čemu imaju ključnu ulogu u izvršenju stanične smrti. Tumori nastaju nekontroliranom proliferacijom stanica, koja je, među ostalim, uzrokovana upravo gubitkom kontrole stanične smrti. Time dolazi do preživljavanja tumorskih stanica te u konačnici metastaziranja tumora. Novija se istraživanja se usmjeravaju na kaspaze kao ciljne molekule u liječenju tumora, odnosno regulaciju njihova djelovanja kojom bi se pospješila apoptoza u tumorskim stanicama. Upotrebom inhibitora ili aktivatora kaspaza može se utjecati na sudbinu stanice, odnosno na njeno preživljavanje ili smrt. Cilj je pronaći lijek sa što manje nuspojava, bez utjecaja na zdrave stanice.
Abstract (english)
Caspases are a proteases with a conserved cysteine residue at their active site. There enzymes cleave their substrates after an aspartate residue. They have role in various cellular processes, including apoptosis, differentiation and inflammatory responses. Twelve caspases have been identified in humans and are divided into two groups, caspases involved in the process of apoptosis and caspases involved in inflammatory response. Caspases participating in apoptosis are divided into caspases initiators and caspases effectors. Even though, caspases have an effect on many cellular processes, when it comes to tumors, caspases are most commonly associated with apoptosis, having the crucial role inthe execution of cell death. Tumors are caused by uncontrollable cell proliferation, which is usually a result of the loss of cell death control. This results in the survival of tumor cells and, ultimately, tumor metastasis. Current research is directed to caspases as target molecules in cancer treatment or to the regulation of their activity in order to increase apoptosis in tumor cells. Caspase inhibitor or activator can affect the cell fate, survival or its death. The goal is to find a drug with as little side effects as possible and without affecting the healthy cells.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:382625
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-12-17 10:45:12