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undergraduate thesis
Salicin i derivati salicina
2019. urn:nbn:hr:182:716984
Rajić, Martina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Rajić, M. (2019). Salicin i derivati salicina (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:716984

Rajić, Martina. "Salicin i derivati salicina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:716984

Rajić, Martina. "Salicin i derivati salicina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:716984

Rajić, M. (2019). 'Salicin i derivati salicina', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:716984

Rajić M. Salicin i derivati salicina [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2019 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:182:716984

M. Rajić, "Salicin i derivati salicina", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:182:716984

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Metadata
TitleSalicin i derivati salicina
Title (english)Salicine and its derivatives
AuthorMartina Rajić
MentorAleksandar Sečenji (mentor)
MentorDajana Gašo-Sokač (komentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2019-09-06, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Salicin je prvi fenolni glukozid pronađen u prirodi, a oralnom primjenom metabolizira u farmakološki aktivni oblik salicilnu kiselinu. Postoji mnogo derivata salicilne kiseline, od kojih je jedan najpoznatiji i najviše korišten lijek, acetilsalicilna kiselina ili Aspirin®. Aspirin je lijek koji ima svojstvo antipiretika i antikoagulanta, a djeluje tako što inhibira aktivnost enzima kao ciklooksigenaze koji dovodi do stvaranja prostaglandina, tvari odgovorne za upalu i bol. Najpoznatija metoda sinteze acetilsalicilne kiseline je esterifikacija salicilne kiseline acetanhidridom uz fosfatnu ili sumpornu kiselinu. Cilj završnog rada bio je ispitati mogućnost sinteze acetilsalicilne kiseline reakcijom esterifikacije salicilne kiseline acetanhidridom konvencionalnom metodom, ali uz uporabu eutektičkih otapala na bazi kolin-klorida (ChCl) za koja se može pretpostaviti katalitička uloga u reakciji esterifikacije. Rezultati eksperimentalnog rada pokazali su da se eutektičko otapalo ChCl: levulinska kiselina i ChCl: limunska kiselina ne mogu koristiti kao katalizator u sintezi acetilsalicilne kiseline. Međutim, uz uporabu eutektičkog otapala ChCl : urea dobivena je acetilsalicilna kiselina pri čemu je po prvi puta potvrđena mogućnost primjene eutektičkih otapala u sintezi acetilsalicilne kiseline.
Abstract (english)
Salicin is the first phenolic glucoside found in nature and after oral use it is metabolized to a pharmacologically active form, salicylic acid. There are many salicylic acid derivatives, one of which is the most commonly used drug, acetylsalicylic acid or aspirin. Aspirin is a medicine that has antipyretic and anticoagulant properties and acts by inhibiting activity of the enzyme cyclooxygenase which is responsible for the production of prostaglandins, substances responsible for inflammation and pain. The most known method of aspirin synthesis is esterification of salicylic acid with acetic anhydride with phosphoric or sulfuric acid. The aim of final thesis was to investigate the possibility of aspirin synthesis by conventional method, but with the use of choline chloride (ChCl) eutectic solvents for which a catalytic role in the esterification reaction can be assumed. The results of the experimental work showed that the eutectic solvents ChCl: levulinic acid and ChCl: citric acid can’t be used as catalyst for the acetylsalicylic acid synthesis. However, with the use of eutectic solvent ChCl: urea, acetylsalicylic acid was obtained and for the first time the possibility of using eutectic solvent in the acetylsalicylic acid synthesis was confirmed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:716984
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2019-12-06 11:54:37