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undergraduate thesis
Biosinteza i biokemija niacina
2020. urn:nbn:hr:182:535902
Štingl, Klara
Josip Juraj Strossmayer University of Osijek
Department of Chemistry

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Štingl, K. (2020). Biosinteza i biokemija niacina (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:535902

Štingl, Klara. "Biosinteza i biokemija niacina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:182:535902

Štingl, Klara. "Biosinteza i biokemija niacina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:182:535902

Štingl, K. (2020). 'Biosinteza i biokemija niacina', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:535902

Štingl K. Biosinteza i biokemija niacina [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2020 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:182:535902

K. Štingl, "Biosinteza i biokemija niacina", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:182:535902

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Metadata
TitleBiosinteza i biokemija niacina
Title (english)Bioosythesis and biochemistry of niacin
AuthorKlara Štingl
MentorAna Amić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
Osijek
Defense date and country2020-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Niacin (vitamin B3) jedan je od 8 B-kompleks vitamina. Dolazi u obliku nikotinske kiseline, nikotinamida i nikotinamid ribozida. Nikotinska kiselina i nikotinamid su slične topljivosti u vodi. Otkriću niacina je prethodila epidemija pelagre, bolesti uzrokovane deficitom niacina u tijelu, koja se javila krajem 19.-og stoljeća. Moguća je biosinteza niacina iz triptofana, a on svoju glavnu ulogu ima kao nukleotid \( NAD^{+}\) i \( NADP^{+}\) te sudjeluje u preko 400 redoks reakcija kao koenzim. Osim enzimatski potpomognutih reakcija, \( NAD^{+}\) sudjeluje i kao supstrat u mnogim reakcijama, od kojih su najbitnije one zaslužne za popravak DNA. U posljednje je vrijeme dana velika pažnja niacinu kao lijeku. U visokim koncentracijama se koristi kao lijek za snižavanje povišene koncentracije kolesterola u krvi, ali i u dermatološke svrhe kao lijek protiv crvenila i nepravilnosti kože.
Abstract (english)
Niacin (vitamin B3) is one of 8 B-complex vitamins. It comes in forms of nicotinic acid, nicotinamide and nicotinamide riboside. Nicotinic acid and nicotinamide have similar solubility in water. Pellagra outbreak in the 19th century preceded the discovery of niacin, a disease caused by a deficit of niacin in the body. A biosynthesis of niacin from tryptophan is possible, but his main role is in the form of \( NAD^{+}\) and \( NADP^{+}\) where it participates in over 400 redox reactions as a coenzyme. Apart from enzymatic reactions, \( NAD^{+}\) participates also as a substrate in many reactions, of which the most important ones being those responsible for DNA repair. Recently, light has been shed on niacin as a drug. In high concentrations it is used as a medicine for lowering high cholesterol in blood, as well as in dermatology as a cure for redness and imperfections of the skin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:535902
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-12-14 11:55:13