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master's thesis
Degradacija farmaceutika pod djelovanjem gama zračenja
2021. urn:nbn:hr:182:911789
Blažek, Karlo
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of General, Inorganic and Physical Chemistry and Methodology of Chemistry

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Blažek, K. (2021). Degradacija farmaceutika pod djelovanjem gama zračenja (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:911789

Blažek, Karlo. "Degradacija farmaceutika pod djelovanjem gama zračenja." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:911789

Blažek, Karlo. "Degradacija farmaceutika pod djelovanjem gama zračenja." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:911789

Blažek, K. (2021). 'Degradacija farmaceutika pod djelovanjem gama zračenja', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:911789

Blažek K. Degradacija farmaceutika pod djelovanjem gama zračenja [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2021 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:182:911789

K. Blažek, "Degradacija farmaceutika pod djelovanjem gama zračenja", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:182:911789

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Metadata
TitleDegradacija farmaceutika pod djelovanjem gama zračenja
Title (english)Degradation of pharmaceutical residues by gamma radiation
AuthorKarlo Blažek
MentorBrunislav Matasović (mentor)
MentorIvana Tartaro Bujak (mentor)
MBZ: 315570
Committee memberMarija Jozanović (predsjednik povjerenstva)
Committee memberBrunislav Matasović (član povjerenstva)
Committee memberAna Amić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of General, Inorganic and Physical Chemistry and Methodology of Chemistry)
Osijek
Defense date and country2021-10-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Inorganic Chemistry
Abstract
Cilj ovog rada bio je ispitati utjecaj gama-zračenja na degradaciju vodene otopine doksazosina, lijeka koji je poznati antihipertenziv i jedan od često korištenih farmaceutika. Istraživanje se provodilo u Laboratoriju za radijacijsku kemiju i dozimetriju, Zavoda za kemiju materija, Instituta Ruđer Bošković. Učinkovitost degradacije proučavana je pri različitim dozama zračenja, brzinama doza, pH vrijednostima otopine, u prisustvu hvatača radikala i u prisustvu anorganskih soli. Ozračeni uzorci analizirani su spektrofotometrijski i tekućinskom kromatografijom visoke djelotvornosti s DAD detektorom. Pokazano je da su •OH glavne reaktivne vrste odgovorne za razgradnju doksazosina, a efikasnost razgradnje polaznog spoja raste s porastom doze gama-zračenja. Prisutnost nitrata je imala značajniji utjecaj na razgradnju doksazosina u usporedbi s karbonatima i fosfatima. Optimalna pH vrijednost za razgradnju vodene otopine doksazosina je u neutralnom, blago kiselom području (pH = 6,5), dok je pri izrazito kiselim i baznim uvjetima razgradnja bila slabija. Utvrđeno je da je razgradnja doksazosina u bunarskoj vodi sporija u usporedbi s ultračistom vodom što ukazuje da organske i anorganske komponente otopljene u vodama utječu na efikasnost radiolitičke degradacije doksazosina.
Abstract (english)
The aim of this study was to investigate the effect of gamma-radiation on the degradation of doxazosin (a widely used antihypertensive drug) in aqueous solution. The research was conducted at the Radiation Chemistry and Dosimetry Laboratory, Division of Materials Chemistry, Ruđer Bošković Institute. The efficiency of degradation was studied under different absorbed doses, dose rates, pH values and in the presence of radical scavengers and inorganic ions. The irradiated samples were analyzed by UV/VIS spectrophotometry and high performance liquid chromatography with diode array detector. It was found that •OH are the main reactive species responsible for the degradation of doxazosin, the efficiency of degradation being higher with increasing dose of gamma radiation. The presence of nitrates had a stronger effect on doxazosin degradation compared to carbonates and phosphates. An optimal pH for doxazosin degradation was in the neutral, slightly acidic range (pH = 6.5), while degradation was slower under extremely acidic or alkaline conditions. It was found that the degradation of doxazosin in well water was much slower compared to ultrapure water, suggesting that organic and inorganic components dissolved in natural waters influence the efficiency of radiolitic degradation of doxazosin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:911789
Study programmeTitle: Graduate University Study of Chemistry; research program; specializations in: Research program
Course: Research program
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-08-03 08:51:29