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undergraduate thesis
Sinteza i IR spektroskopska analiza aspirina i paracetamola
2012. urn:nbn:hr:182:843734
Lovrek, Kristina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry

Cite this document

Lovrek, K. (2012). Sinteza i IR spektroskopska analiza aspirina i paracetamola (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:843734

Lovrek, Kristina. "Sinteza i IR spektroskopska analiza aspirina i paracetamola." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2012. https://urn.nsk.hr/urn:nbn:hr:182:843734

Lovrek, Kristina. "Sinteza i IR spektroskopska analiza aspirina i paracetamola." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2012. https://urn.nsk.hr/urn:nbn:hr:182:843734

Lovrek, K. (2012). 'Sinteza i IR spektroskopska analiza aspirina i paracetamola', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 26 October 2024, https://urn.nsk.hr/urn:nbn:hr:182:843734

Lovrek K. Sinteza i IR spektroskopska analiza aspirina i paracetamola [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2012 [cited 2024 October 26] Available at: https://urn.nsk.hr/urn:nbn:hr:182:843734

K. Lovrek, "Sinteza i IR spektroskopska analiza aspirina i paracetamola", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:182:843734

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Metadata
TitleSinteza i IR spektroskopska analiza aspirina i paracetamola
AuthorKristina Lovrek
MentorNela Malatesti (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
Osijek
Defense date and country2012, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj rada je sintetizirati organske spojeve acetilsalicilnu kiselinu i acetaminofen i okarakterizirati ih snimanjem njihovih IR spektara. Ova tema je izabrana radi boljeg upoznavanja povijesti, načina dobivanja i karakteristika dvaju najpoznatijih farmaceutskih proizvoda današnjice – aspirina i paracetamola,te korištenja IR spektroskopije kao instrumentalne analize koja se, među ostalim, često primjenjuje u analizi poznatih organskih spojeva. Oba spoja dobivena su reakcijama esterifikacije. Aspirin® je dobiven reakcijom acetatnog anhidrida i salicilne kiseline uz mineralnu kiselinu kao katalizator. Paracetamol je dobiven reakcijom acetatnog anhidrida i p-aminofenola, također u kiseloj sredini. Mehanizam takvih reakcija je nukleofilna adicija-eliminacija. Eksperimentalno iskorištenje za aspirin je 50.5%, a za paracetamol 36.3%. Snimljeni su IR spektri dobivenih spojeva te je uočeno dobro preklapanje sa literaturnim spektrima. Ovim radom se dokazalo da su aspirin i paracetamol lijekovi koje je lako dobiti iz jeftinih sirovina, a zbog svojih svojstava, sigurni za upotrebu kod većine ljudi (iznimka su osobe s ozbiljnim gastrointestinalnim tegobama).
Abstract (english)
The aim of this work is to synthesise organic compounds, acetylsalicylic acid and paracetamol and to characterize them by infrared spectroscopy. This topic is chosen to understand better the history, methods for synthesis and characteristics of two of the most famous contemporary drugs - aspirin and paracetamol, and to apply IR spectroscopy as an important instrumental method that can be used in analysis of known organic compounds. Both compounds were prepared through esterification reactions. Aspirin® is obtained from the reaction of acetic anhydride with salicylic acid and mineral acid as a catalyst. Paracetamol is obtained from the reaction of acetic anhydride with p-aminophenol, also with mineral acid as catalyst. Mechanism of both reactions is described as nucleofilic addition-elimination. The obtained yield for aspirin is 51%, and for paracetamol 36%. IR spectra of obtained compounds were recorded and they are in accordance with literature spectra. It was proved that aspirin and paracetamol are drugs that can be easily obtained from cheap chemicals, and it is known that due to their properties most people can safely use them (excluding people with serious gastrointestinal difficulties).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:843734
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2016-07-12 07:23:52