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undergraduate thesis
Kemija imunoloških reakcija na tumore
2024. urn:nbn:hr:182:660578
Plećko, Ines
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Plećko, I. (2024). Kemija imunoloških reakcija na tumore (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:660578

Plećko, Ines. "Kemija imunoloških reakcija na tumore." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:660578

Plećko, Ines. "Kemija imunoloških reakcija na tumore." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:660578

Plećko, I. (2024). 'Kemija imunoloških reakcija na tumore', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 18 February 2025, https://urn.nsk.hr/urn:nbn:hr:182:660578

Plećko I. Kemija imunoloških reakcija na tumore [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2024 [cited 2025 February 18] Available at: https://urn.nsk.hr/urn:nbn:hr:182:660578

I. Plećko, "Kemija imunoloških reakcija na tumore", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:182:660578

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Metadata
TitleKemija imunoloških reakcija na tumore
Title (english)Chemistry of immunological reactions to tumors
AuthorInes Plećko
MentorAna Amić (mentor)
Committee memberOlivera Galović (predsjednik povjerenstva)
Committee memberAna Amić (član povjerenstva)
Committee memberAnamarija Stanković (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2024-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Applied Chemistry
Abstract
U ovom radu istraduju se biokemijski procesi koje se odvijaju u organizmu prije te tijekom nastanka tumora. Opisuje se imunologija organizma te preduvjeti koji su potrebni za nastanak tumora. Istradene su molekule koje su uklju ene u biokemijske procese nastanka tumora, patogeneza te kancerogeneza. Imunolobki sustav mode prepoznati maligno transformirane stanice zahvaljuju i antigenima koji razlikuju tumorsku stanicu od normalne. Upala u mikrookrudenju tumora uzrokuje nakupljanje imunolobkih stanica na tom mjestu, stoga tumor ima neke mehanizme imunolobke supresije u mikrookrudenju kako bi izbjegao imunolobki nadzor. Zaklju no tome ukoliko je prisutan stani ni stres, mutacije, genetske predispozicije te razni imbenici povezani sa samim kemijskim molekulama to e rezultirati pojavom procesa koji ine razliku izme u tumora i normalnih stanica. Fosfatidilserin (PS) je fosfolipid koji se u normalnim stanicama nalazi na unutarnjoj strani membrane, ali tijekom apoptoze prelazi na vanjsku stranu, signaliziraju i fagocitima za uklanjanje stanice. PS tako er igra ulogu u imunosupresiji, bto tumorske stanice iskoribtavaju za izbjegavanje imunolobkog odgovora. NK stanice su klju ne za imunolobku obranu, prepoznaju i ubijaju tumorske i zaradene stanice. B7–H6 protein, prisutan na tumorskim stanicama, aktivira NK stanice putem NKp30 receptora, poti u i njihovu citotoksi nost.
Abstract (english)
This thesis investigates the biochemical processes occurring in the body before and during tumor development. It describes the body's immunology and the prerequisites necessary for tumor formation. Molecules involved in the biochemical processes of tumorigenesis, pathogenesis, and carcinogenesis are explored. The immune system can recognize malignantly transformed cells thanks to antigens that distinguish tumor cells from normal ones. Inflammation in the tumor microenvironment causes immune cells to accumulate at that site, prompting tumors to develop mechanisms of immune suppression in the microenvironment to evade immune surveillance. Consequently, if cellular stress, mutations, genetic predispositions, and various factors related to chemical molecules are present, they will result in processes that differentiate tumors from normal cells. Phosphatidylserine (PS) is a phospholipid that, in normal cells, is found on the inner side of the membrane but during apoptosis moves to the outer side, signaling phagocytes to remove the cell. PS also plays a role in immunosuppression, which tumor cells exploit to evade the immune response. NK cells are crucial for immune defense, recognizing and killing tumor and infected cells. The B7–H6 protein, present on tumor cells, activates NK cells via the NKp30 receptor, promoting their cytotoxicity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:660578
Study programmeTitle: University Undergraduate Study program Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-04 11:23:55