Supramolecular chemistry is defined as the “chemistry of molecular systems and intermolecular connections” or simply as “chemistry above the molecule”. It is a "young" scientific discipline that began to develop significantly in the late 1960s and early 1970s. Supramolecular chemistry is a multidisciplinary field with the focus on intermolecular interactions and supramolecular aggregates whose building blocks are molecules. The supramolecular aggregate is a compound which is held by non-covalent interactions between the two or more covalently linked molecules or ions. It can be divided into two broad categories: host-guest chemistry and self-assembly or molecular self-organization. In this paper more detailed description will be given of host-guest chemistry and related compounds. The host is most often a molecule possessing a convergent centered cavity of a certain size. A guest can be a cation, a simple inorganic anion, an ion pair, or a sophisticated molecule such as a hormone, a pheromone or a neurotransmitter possessing a divergent binding site. The host-guest complexes range from very simple (chlorine hydrate, methane clathrate) to much more complex (cyclodextrin, zeolites, metal-organic framework) structures that combine organic and inorganic chemistry together with biochemistry, nanotechnology and chemical engineering. Supramolecular chemistry, and therefore the host-guest chemistry, is developing rapidly over these 30 years and over. Today, it is characterized by a wide range and variety of compounds that are applicable in biochemical, pharmaceutical, ecological, cosmetic, nutritional and many other industries and there is still plenty of room for improvement.