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master's thesis
Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva
2023. urn:nbn:hr:182:617128
Horvat, Ana
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Horvat, A. (2023). Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:617128

Horvat, Ana. "Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:182:617128

Horvat, Ana. "Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:182:617128

Horvat, A. (2023). 'Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 12 May 2024, https://urn.nsk.hr/urn:nbn:hr:182:617128

Horvat A. Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2023 [cited 2024 May 12] Available at: https://urn.nsk.hr/urn:nbn:hr:182:617128

A. Horvat, "Sinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:182:617128

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Metadata
TitleSinteza kvaternih soli N-acihidrazinskih derivata heterocikličkih spojeva
Title (english)Synthesis of quaternary salts of N-acylhydrazine derivatives of heterocyclic compounds
AuthorAna Horvat
MentorMartina Šrajer Gajdošik (mentor)
MentorDajana Gašo-Sokač (komentor)
Committee memberMarija Jozanović (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberDajana Gašo-Sokač (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2023-07-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Zbog svoje važne biološke aktivnosti promatran je i ispitivan vitamin B6 i njegovi derivati. Važnost vitamina B6 očituje se u normalnom funkcioniranju živčanog sustava te normalnom funkcioniranju metabolizma lipida, glukoze, aminokiselina. Bitnu ulogu ima i u brojnim enzimskim aktivnostima. Molekula piridoksala pruža široke mogućnosti za kemijske modifikacije i pripravu derivata sa značajnim farmakološkim djelovanjem. U radu se pripravljeni derivati piridoksal hidroklorida. Prvo su sintetizirani N-acilhidrazoni (1-8), reakcijom piridoksala sa N-acilhidrazinima aromatskih i heteroaromatskih spojeva. Reakcije su rađene klasičnim putem, miješanjem u etanolu na sobnoj temperaturi 24 sata. U drugom dijelu rada se dobiveni hidrazoni kvaterniziraju s ciljem dobivanja kvaternih soli. Za kvaternizaciju se koriste fenacil-bromidi i supstituirani fenacil-bromidi. Sinteza se izvodi klasičnim putem, miješanjem i zagrijavanjem pri temperaturi refluksa otapala. Svi dobiveni spojevi su pročišćeni i snimljeni su im IR, MS, 1H i 13C NMR spektri, te im je određena temperatura tališta.
Abstract (english)
Because of its important biological activity, vitamin B6 and its derivatives have been observed and investigated. The importance of vitamin B6 is manifested in the normal functioning of the nervous system and the normal functioning of the metabolism of lipids, glucose, and amino acids. It also plays an important role in numerous enzymatic activities. The pyridoxal molecule offers wide possibilities for chemical modifications and the preparation of derivatives with significant pharmacological activity. Pyridoxal hydrochloride derivatives are prepared in this work. First, N-acylhydrazones (1-8) were synthesized, by reacting piridoxal with N-acylhydrazines of aromatic and heteroaromatic compounds. The reactions were carried out in the classic way, by stirring in ethanol at room temperature for 24 hours. In the second part of the work, the obtained hydrazones are quaternized with the aim of obtaining quaternary salts. Phenacyl bromides and substituted phenacyl bromides are used for quaternization. The synthesis is carried out in the classical way, by mixing and heating at the reflux temperature of the solvent. All obtained compounds were purified and their IR, MS, 1H and 13C NMR spectra were recorded, and their melting point was determined.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:617128
Study programmeTitle: Graduate University Study of Chemistry; research program; specializations in: Research program
Course: Research program
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-08-31 09:15:40