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undergraduate thesis
Metode priprave O-glikozida
2024. urn:nbn:hr:182:910821
Krmpotić, Nikola
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Krmpotić, N. (2024). Metode priprave O-glikozida (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:910821

Krmpotić, Nikola. "Metode priprave O-glikozida." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:910821

Krmpotić, Nikola. "Metode priprave O-glikozida." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:910821

Krmpotić, N. (2024). 'Metode priprave O-glikozida', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:910821

Krmpotić N. Metode priprave O-glikozida [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2024 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:182:910821

N. Krmpotić, "Metode priprave O-glikozida", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:182:910821

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Metadata
TitleMetode priprave O-glikozida
Title (english)Methods of O-glycosides preparation
AuthorNikola Krmpotić
MentorMartina Šrajer Gajdošik (mentor)
Committee memberVlatka Gvozdić (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberElvira Kovač-Andrić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2024-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Ugljikohidrati se ubrajaju među najva~nije biolobke makromolekule, a u prirodi se esto pojavljuju u obliku glikozida. Po kemijskom sastavu, glikozidi su mijebani acetali, naj eb e sastavljeni od be ernog dijela koji je glikozidnom vezom povezan s nebe ernim aglikanskim dijelom na anomernom ugljikovom atomu. Metode njihove sinteze uklju uju uvođenje zabtitnih skupina kako bi se postigla kemoselektivnost reakcije, aktivaciju glikozidnih donora pomo u raznih katalizatora i kona no, nukleofilni napad glikozidnog akceptora. Osim tradicionalnih metoda, u novije vrijeme razvijene su napredne sintetske strategije, poput „one-pot“ sinteze i primjene „armed-disarmed“ koncepta, koje omogu uju u inkovitiju i br~u sintezu s manjim brojem koraka i boljom kontrolom reakcije u kontekstu isto e produkta i prinosa reakcije. Ove inovacije ne samo da pojednostavljuju sintezu glikozida, ve otvaraju mogu nosti za njihovu biru primjenu. Ovaj rad istra~uje biolobku va~nost O-glikozida i detaljno analizira tradicionalne i suvremene metode njihove sinteze.
Abstract (english)
Carbohydrates are among the most important biological macromolecules, and in nature, they often occur in the form of glycosides. Chemically, glycosides are mixed acetals, typically composed of a sugar unit linked to the non-sugar aglycon moiety via a glycosidic bond through the anomeric center. Methods of their synthesis involve the introduction of protecting groups in order to achieve chemoselectivity in the reaction, activation of glycoside donors using various catalysts, and finally, nucleophilic attack of the glycoside acceptor. In addition to traditional methods, advanced synthetic strategies have been recently developed, such as one-pot synthesis and the armeddisarmed concept, which enabled a more efficient synthesis with fewer synthetic steps and better control of the reaction in the context of product purity and reaction yield. These innovations not only simplify glycoside synthesis but also open the possibility for wider application. This paper explores the biological significance of O-glycosides and provides a detailed analysis of traditional and contemporary methods of their synthesis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:910821
Study programmeTitle: University Undergraduate Study program Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-10-04 08:47:14