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undergraduate thesis
Disfunkcije metabolizma sfingolipida
2018. urn:nbn:hr:182:331978
Hefer, Marija
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Hefer, M. (2018). Disfunkcije metabolizma sfingolipida (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:331978

Hefer, Marija. "Disfunkcije metabolizma sfingolipida." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:331978

Hefer, Marija. "Disfunkcije metabolizma sfingolipida." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:331978

Hefer, M. (2018). 'Disfunkcije metabolizma sfingolipida', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 21 January 2025, https://urn.nsk.hr/urn:nbn:hr:182:331978

Hefer M. Disfunkcije metabolizma sfingolipida [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2018 [cited 2025 January 21] Available at: https://urn.nsk.hr/urn:nbn:hr:182:331978

M. Hefer, "Disfunkcije metabolizma sfingolipida", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:182:331978

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Metadata
TitleDisfunkcije metabolizma sfingolipida
Title (english)Sphingolipid metabolism dysfunctions
AuthorMarija Hefer
MentorMartina Šrajer Gajdošik (mentor)
MentorMarija Paurević (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2018-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Sfingolipidi su glavne komponente staničnih membrana u živčanom sustavu svih eukariota. S obzirom da su uklopljeni u stanične membrane, oni kontroliraju i bitne stanične signalne puteve. Najveću ulogu u staničnoj signalizaciji ima ceramid koji inducira staničnu smrt mijenjajući pritom strukturu membrana. Ostali sfingolipidi koji su odgovorni za izgradnju dijele se na glikosfingolipide i fosfosfingolipide. Disfunkcijom metabolizma bilo kojeg sfingolipida dolazi do njihovog nakupljanja, a samim time i pojave neuroloških oboljenja. Lizosomske bolesti nakupljanja kod kojih dolazi do pogrešne razgradnje i skladištenja tih lipida nazivaju se sfingolipidoze. Sfingolipidoze su nasljedne bolesti uzrokovane nedostatkom enzima za razgradnju ili sfingolipid aktivirajućih proteina (SAP). Iako terapije za većinu tih bolesti nisu dostupne zbog neistraženosti njihove etiologije, daljnjim istraživanjima otkrivaju se nove potencionalne metode za njihovo liječenje.
Abstract (english)
Sphingolipids are the main constituents of cell membranes in the nervous system of all eukaryotes. Being embedded in the cell membranes they also control some of the most important cellular signaling pathways. Ceramide plays a major role in intracellular signaling, changing the structure of cell membranes and thereby inducing the apoptosis. The remaining sphingolipids that act as building blocks are divided into glycosphingolipids and phosphosphingolipids. Dysfunctions in sphingolipid metabolism lead to their accumulation in lysosomes, acting as a trigger for neurological disorders. Lysosomal storage diseases, which arise because of the defects in degradation and storage of sphingolipids, are called sphingolipidoses. Sphingolipidoses are a group of hereditary genetic diseases caused by a lack of sphingolipid-degrading enzymes or sphingolipid activator proteins (SAP). Treatments for most of these diseases are not yet established because of the poor understanding of their ethiologies, although, novel studies are discovering potentially new methods for their treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:331978
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-12-17 08:59:28