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master's thesis
Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija
2019. urn:nbn:hr:182:146529
Andrijević, Martina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Andrijević, M. (2019). Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:146529

Andrijević, Martina. "Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:146529

Andrijević, Martina. "Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:146529

Andrijević, M. (2019). 'Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 27 May 2023, https://urn.nsk.hr/urn:nbn:hr:182:146529

Andrijević M. Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2019 [cited 2023 May 27] Available at: https://urn.nsk.hr/urn:nbn:hr:182:146529

M. Andrijević, "Sinteza novog fluorescentnog indikatora za određivanje koncentracije selenija", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:182:146529

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Metadata
TitleSinteza novog fluorescentnog indikatora za određivanje koncentracije selenija
Title (english)Synthesis of the new fluorescence indicator for determination of selenium concentration
AuthorMartina Andrijević
MentorAleksandar Sečenji (mentor)
Committee memberMartina Šrajer Gajdošik (predsjednik povjerenstva)
Committee memberAleksandar Sečenji (član povjerenstva)
Committee memberMarija Jozanović (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2019-10-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U ovome radu opisana je priprava spoja 7a,: 5,6-diamino-2-propil-1H-benzo [de] izokinolin-1,3 (2H)-diona, u svrhu selektivnog kompleksiranja i fluorescentne kvantifikacije koncentracije selenija. Kao polazni spoj u sintezi spoja 7a odabran je 4-brom-1,8-naftalanhidrid (1). Prvi korak podrazumijevao je prevođenje spoja 1, reakcijom s odgovarajućim primarnim aminima, u njegove imidne derivate (2a, 2b i 2c). Za provođenje daljnjih sintetskih koraka korišten je jedan od pripravljenih imidnih derivata, spoj 2a. Slijedeći korak podrazumijevao je reakciju spoja 2a s natrijevim azidom što je rezultiralo supstitucijom broma azidnom skupinom, nakon čega slijedi redukcija azidne skupine u amino skupinu (4a). Daljnji sintetski koraci obuhvaćaju halogeniranje aromatskog sustava reakcijom spoja 4a s bromnom vodom čime se htjelo postići selektivno uvođenje broma na ortho položaj u odnosu na već prisutnu amino skupinu (5a). Nakon toga slijedi supstitucija broma azidnom skupinom (6a) te u konačnici redukcija novo uvedene azidne skupine u amino skupinu (7a). Strukture većine spojeva pretpostavljene su IR spektroskopijom i/ ili \( ^{1}H \) i \( ^{13}C \) NMR spektroskopijom.
Abstract (english)
In this diploma thesis synthesis of compound 7a, 5,6-diamino-2-propyl-1H-benzo [de] isoquinoline-1,3 (2H)-dione is described. The purpose of synthesis of this compound is selective complexation and fluorescent quantification of selenium concentration. As starting compound in this synthesis 4-bromo-1,8-naphthalanhdride was used (1). In first step compound 1 reacts with different primary amines to give imide derivatives, compounds 2a, 2b and 2c. In the following steps only compound 2a was used as a starting material for preparation of target compund, compound 7a. Compound 2a reacts with sodium azide and this step is including substitution of bromine with azido group (3a). Azido group of compound 3a was reduced to amino group by introduction of hydrogen sulfide into reaction mixture (4a). The following step inolved halogenation of compund 4a by reaction with bromine water to achieve introduction of bromine in ortho position to amino group (5a). Compound 5a by reaction with sodium azide gave compund 6a and finally azido group of compound 6a was reduced by introduction of hydrogen sulfide into reaction mixture to give target compund, 7a.The structures of most compounds were assumed by IR spectroscopy and/or NMR spectroscopy ( \( ^{1}H \),\( ^{13}C \) ).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:146529
Study programmeTitle: Graduate University Study of Chemistry; research direction
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-14 12:13:38