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master's thesis
Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina
2022. urn:nbn:hr:182:942449
Budeš, Ana-Marija
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Budeš, A. M. (2022). Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:942449

Budeš, Ana Marija. "Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:942449

Budeš, Ana Marija. "Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:942449

Budeš, A. M. (2022). 'Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 09 December 2024, https://urn.nsk.hr/urn:nbn:hr:182:942449

Budeš AM. Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2022 [cited 2024 December 09] Available at: https://urn.nsk.hr/urn:nbn:hr:182:942449

A. M. Budeš, "Razvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:182:942449

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Metadata
TitleRazvoj i optimizacija novog potenciometrijskog senzora za određivanje prometazina
Title (english)Development and optimization of the new potentiometric sensor for determination of promethazine
AuthorAna-Marija Budeš
MentorMirela Samardžić (mentor)
MentorMateja Budetić (pomoć pri izradi, neposredni voditelj)
Committee memberMarija Jozanović (predsjednik povjerenstva)
Committee memberMirela Samardžić (član povjerenstva)
Committee memberElvira Kovač-Andrić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2022-10-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Prometazin hidroklorid (PM) je derivat fenotiazina koji se koristi kao antagonist H1-receptora, lokalni anestetik, antiemetik, sedativ, antialergijsko sredstvo, antikoronavirusno sredstvo i geroprotektor. Može uzrokovati štetne učinke kod ljudi, poput endokrinih, srčanih i reproduktivnih promjena, stoga je iznimno važno razviti nove metode za njegovo određivanje u komercijalnim formulacijama i biološkim uzorcima. Cilj ovog rada je razvoj i optimizacija potenciometrijskog senzora za određivanje PM temeljenog na ionskom paru kationa prometazina i tetrafenilboratnog aniona (PM-TPB) kao elektroaktivnom materijalu, koji je ugrađen u tekuću membranu elektrode. Kako bi se dobila optimalna membrana za potenciometrijski senzor, ispitan je utjecaj vrste plastifikatora i udjela elektroaktivnog materijala na karakteristike PM-TPB senzora. Utvrđeno je da optimalna membrana PM-TPB senzora u svom sastavu ima 66% o-nitrofenil oktil etera kao plastifikatora, 33% polivinil klorida i 1% elektroaktivnog materijala. Senzor je pokazao nagib od 56,2 mV po dekadi aktiviteta, široko mjerno područje od 6,17∙10-7 do 5,0∙10-3 mol/dm3 i nisku granicu detekcije od 1,25∙10-7 mol/dm3.
Abstract (english)
Promethazine hydrochloride (PM) is a phenothiazine derivative used as an H1-receptor antagonist, local anesthetic, antiemetic, sedative, antiallergic agent, anticoronavirus agent and geroprotector. It can cause adverse effects in humans, such as endocrine, cardiac and reproductive changes, so it is extremely important to develop new methods for its determination in commercial formulations and biological samples. The aim of this work is the development and optimization of a potentiometric sensor for the determination of PM based on the ion pair of promethazine cation and tetraphenylborate anion (PM-TPB) as an electroactive material, which is embedded in the liquid membrane of the electrode. In order to obtain an optimal membrane for the potentiometric sensor, the influence of the type of plasticizer and the percentage of electroactive material on the characteristics of the PM-TPB sensor was examined. It was determined that the optimal PM-TPB sensor membrane has 66% of o-nitrophenyl octyl ether as a plasticizer, 33% of polyvinyl chloride and 1% of electroactive material. The sensor showed a slope of 56.2 mV per decade of activity, a wide measurement range from 6.17∙10-7 to 5.0∙10-3 mol/dm3 and a low detection limit of 1.25∙10-7 mol/dm3.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:942449
Study programmeTitle: Graduate University Study of Chemistry; research program; specializations in: Research program
Course: Research program
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-11-02 13:03:21