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master's thesis
Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova
2024. urn:nbn:hr:182:293663
Čavlek, Aleksandra
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Čavlek, A. (2024). Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:293663

Čavlek, Aleksandra. "Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:293663

Čavlek, Aleksandra. "Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:293663

Čavlek, A. (2024). 'Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:293663

Čavlek A. Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2024 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:182:293663

A. Čavlek, "Sinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:182:293663

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Metadata
TitleSinteza novih piridoksaliminskih derivata potencijalnih višeciljnih lijekova
Title (english)Synthesis of novel pyridoxalimine derivatives as possible multitargeted drugs
AuthorAleksandra Čavlek
MentorMartina Šrajer Gajdošik (mentor)
MentorDajana Gašo-Sokač (komentor)
Committee memberMarija Jozanović (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberDajana Gašo-Sokač (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2024-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Zelena kemija ili odr~iva kemija je nov na in razmibljanja koji se sve vibe primjenjuje u kemiji u svrhu o uvanja okoliba i ljudskog zdravlja. Dvanaest principa zelene kemije donijeli su P. Anastas i J. Warner 1998. godine. Mehanokemijska sinteza je metoda zelene sinteze u kojoj se primjenjuje mehani ka sila koju uzrokuju razli ita tijela za mijebanje. Sinteza potpomognuta teku inom (LAG metoda) je vrsta mehanokemijske sinteze u koju se dodaje mala koli ina teku ine, njezina je uloga da pripomogne sintezi i nema ulogu otapala. Vitamin B6 je vitamin koji u svojoj strukturi ima razli ite funkcionalne skupine koje mu omogu uju razli ite kemijske modifikacije. Kvaterne amonijeve soli su organski spojevi gdje su na dubik vezane 4 razli ite skupine. Cilj ovog rada je sinteza kvaternih soli N-acilhidrazonskih derivata vitamina B6 tj. piridoksal hidroklorida. Sinteza novosintetiziranih spojeva se odvijala u vibracijskom mlinu tijekom 4 sata pomo u sinteze potpomognute teku icom. Sintetizirane su dvije serije kvaternih soli sa razli itim polaznim reaktantima koji su reagirali sa supstituiranim fenacil-bromidima. Struktura novosintetizranih produkata je određena pomo u masene spektroskopije.
Abstract (english)
Green chemistry or sustainable chemistry is a new way of thinking that is increasingly applied in chemistry for the purpose of preserving the environment and human health. The twelve principles of green chemistry were adopted by P. Anastas and J. Warner in 1998. Mechanochemical synthesis is a method of green synthesis in which the mechanical force caused by various mixing bodies is applied. Liquid-assisted synthesis (LAG method) is a type of mechanochemical synthesis in which a small amount of liquid is added, its role is to assist the synthesis and it has no role as a solvent. Vitamin B6 is a vitamin that has different functional groups in its structure that allow it to undergo different chemical modifications. Quaternary ammonium salts are organic compounds where 4 different groups are attached to nitrogen. The aim of this work is the synthesis of quaternary salts of N-acylhydrazone derivatives of vitamin B6, i.e. pyridoxal hydrochloride. The synthesis of the newly synthesized compounds took place in a vibrating mill for 4 hours using liquid-assisted synthesis. Two series of quaternary salts were synthesized with different starting reactants that reacted with substituted phenacyl bromides. The structure of the newly synthesized products was determined using mass spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:293663
Study programmeTitle: University Graduate Study of Chemistry; Research Program; specializations in: Research Program
Course: Research Program
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-03 09:53:35