With the development of crystal engineering and the growing need to design materials of specific use, scientists have realized the necessity for a better understanding of intermolecular interactions in crystals. Intermolecular interactions determine a vast number of physical and chemical properties. Crystal engineering gives special preference to macrocyclic supramolecular compounds due to their easy preparation and wide potential use. Although X-ray structural analysis is still the basic way to determine crystal structure, it alone does not provide sufficient insight into the intermolecular interactions that link molecules into crystals. By introducing a new way of describing the electron density of a molecule using the Hirschfeld surface, it is possible to visually display and map the areas involved in intermolecular interactions. With a detail study of the data obtained from the Hirschfeld surface, it is possible to predict the dominant intermolecular interactions, the region of the molecule participating in the interaction, the binding energy, and the way the molecules are packaged into crystals. In this paper, Hirschfeld surface analysis was performed for 9 macrocyclic compounds, of which 8 analyses were successful. The obtained results were then compared with X-ray structural analysis of selected compounds, and some additional intermolecular binding methods in the crystal structure were proposed for some of the molecules.