The immune system is a system that controls all pathogenic species in the organism and thus prevents various damage and diseases. The key reaction is the reaction of antibodies and antigens that stimulate the immune response. The ultimate goal is the apoptosis of the target cell, and it is realized by a series of complex mechanisms involving different proteins, complexes and receptors, with an emphasis on the activation mechanism of T and B cells, and the T-cell selection mechanism is also crucial. With the correct positive and negative selection, T-cell selection mechanism provides an attack on unwanted tissue. In the event of a mistake, the immune system can attack its own antigens, where by autoimmune disorders develop. Autoimmune disorders are divided into two groups: systemic immunity and specific autoimmunity of organs. Systemic autoimmunity involves connective tissue disorders, while specific autoimmunity of organs includes exact organs. The diagnosis is based on the use of biomarkers such as various genes, proteins, receptors and antibodies. The development of autoimmune disorders is also influenced by many factors, most important of which are genetics, sex, age, ethnicity and the environment. Future prospects in the treatment of autoimmune disorder simply the use of drugs such as corticosteroids and immunosuppressive drugs. In addition, important advances in medicine include operations, then the development of new technologies and techniques. First of all, the most influential anti-autoimmune remedy is the responsibility of every man to himself.